The 50-year-old said he saw himself carrying on an ancient human tradition of the roving poet or musician.
"It is an old way of story-telling: the wandering bard. I am curious myself to see how it all turns out. It is the notion of a questing story which we find in all cultures, that you have to go away from home and come back in order to truly discover what 'home' was."
But while Salopek may see himself in the same light as a Homeric character, he will be taking a laptop and video and audio recording tools. Salopek intends to record his journey, from its changing landscapes and its shifting skies and - most importantly of all, perhaps - the voices and faces of the people he meets. Those samples will be taken every 160km or so and stored on a database hosted by an online "journalism laboratory".
It will provide a unique record of a huge slice of the planet at this moment in history. "We will be creating a family portrait of humanity for the next seven years," he said.
No one thinks the journey is going to be easy. The physical challenge of walking from Africa to South America is going to be arduous. But it is virtually impossible to plan ahead for a seven-year journey that will go through some of the globe's most dangerous political hotspots - such as Iran and central America.
Borders will open or close as regimes rise and fall, potentially blocking his way. But Salopek says his journey will not falter. "I will do the same thing as our ancestors did. I will pivot around obstacles," he said.
But he admitted that the mental challenges are likely to be harder than the physical task. He will face long periods of solitude, but at the same time be the centre of global attention.
In order to relieve the pressure, Salopek says he will be going offline for some periods to rest and also because he wants his journey to record real stories, not to be a simple log of kilometres walked, blisters burst and shoes worn out.
His wife, visual artist Linda Lynch, might also join him during some of those breaks.
Although Salopek's journey might seem like a crazed plan, the highly experienced and well-travelled writer said he did not feel intimidated. "I have moved around my whole life. I am very good at moving through different cultural membranes and I feel that I have been unconsciously preparing for this for many years."
His trip, which will be called the Out of Eden Walk, has been backed by numerous sponsors, including the Knight Foundation, Harvard's Nieman Foundation for Journalism and the Pulitzer Centre on Crisis Reporting.
Into the unknown
7 years
3 continents
33,800 kilometres
30m steps
60,000 years of migration retraced
Paul Salopek
During his time working for the Chicago Tribune and National Geographic, Salopek has journeyed all over the world, won two Pulitzer Prizes and earned a reputation for immersive, epic reporting. He once travelled 2000km by mule across Mexico for a story and, while working in Sudan, was arrested as a suspected spy. Elsewhere, he has canoed through Congo and even worked as a commercial fisherman in New England.
- Observer