The video shows three vehicles, a Chevy, a Nissan pick-up, a Sterling tractor and a Toyota waiting behind a stop sign held by a construction crew member ahead of a construction zone, near Coytote Springs, Nervada.
A fifth vehicle approached the scene and the driver failed to brake, hitting all four vehicles.
The driver and passenger in the Toyota, Robert Barnes, 50, and Christopher Markley, 34, were sent flying due to force of impact and were pronounced dead at the scene.
"Investigators believe drowsy driving was a factor in this crash," the Nevada Highway Patrol said.
Fox 5 Vegas quoted Trooper Jason Buratczuk who said "Drowsy driving is just as bad as if you were intoxicated or texting and driving … it impairs your ability to drive a vehicle."
Three other involved in the accident were taken to hospital, including the driver at fault. None of their injuries were life threatening
#trafficalert US93 at mile marker 63, 2x fatal crash involving 4 vehicles. All travel lanes are closed, traffic is being diverted onto SR168. US93 is also closed at IR15. Unknown when roads will reopen, use caution in the area as we investigate. #buckleup#drivesafenv#nhpsocommpic.twitter.com/1D7MRV1z5g
— NHP Southern Command (@NHPSouthernComm) July 18, 2018
At this stage, no charges have been made against the truck driver and the investigation is ongoing.
All lanes were shut down following the crash, with traffic diverted.