Six domestic flights have been exposed to coronavirus after a Virgin cabin crew member tested positive.
Matson said the employee had worked while infectious from October 4-6.
The flights of concern were:
October 4: VA219 from Melbourne to Adelaide
October 4: VA218 from Adelaide to Melbourne
October 5: VA827 from Melbourne to Sydney
October 5: VA808 from Sydney to Melbourne.
October 6: VA1593 from Melbourne to Newcastle.
October 6: VA1594 Newcastle to Melbourne.
"Fellow crew members on those flights have been deemed close contacts and most do live in Melbourne and will be contacted by the department," Matson told reporters on Saturday morning.
Passengers on those flights were also being contacted by their respective jurisdictions.
It comes as Victoria recorded 1965 new local cases of Covid-19 on Saturday, again breaking a national record for the highest number of daily infections.
Five Victorians died from the virus in the past 24 hours.
The deaths included a woman in her 90s and a man in his 70s from Moreland, man in his 60s from Banyule and a man in his 50s from Hume.
A man in his 60s from the western suburbs also died with Covid.
More than 84 per cent of the state's population is now single-dose vaccinated and 56.6 per cent are fully-dosed.
Saturday's case total was a national high and comes just a day after Victoria broke that record on Friday with 1838 cases.
There were 41,177 vaccine doses administered in the past 24 hours and 73,443 Covid-19 test results received.
Mildura in northwest Victoria last night entered a snap seven-day lockdown from 11.59pm on Friday.
The regional city has recently had a rise in Covid-19 infections, with nine active cases in the Mildura Rural City Council local government area reported as of Friday morning.
A further three cases were identified on Friday afternoon and were included in Saturday's numbers, bringing the total number of confirmed infections to 12.
Where to get a vaccination in Auckland - without a booking
This map shows large vaccinations centres from the Unite again Covid-19 information page. For more detailed information about your neighbourhood visit Healthpoint.