A majority `yes' vote in referendum could set wheels in motion for creation of new Republic of Veneto.
There has been much water under the Bridge of Sighs since Napoleon Bonaparte marched into Venice, ending 1100 years of independence in the city state.
But today, more than two centuries after Napoleon barged in, and almost 150 years after Venice finally became part of Italy, the five million citizens of the lagoon and Veneto region could again cut ties with Rome.
Egged on by independence campaigners in Scotland and Catalonia, a majority "Yes" vote could set in train events that see the evocative city once again become the capital of an independent sovereign state.
The referendum, which closes next Sunday, is not recognised by Rome or the regional authorities, but its proponents say a positive outcome could create a head of steam that would make independence inevitable.