Northern League politicians promoting the creation of a new Republic of Veneto say they have history on their side. The Venetian Republic was, they note, one of the most important and enduring states in European history, lasting from the late seventh century until 1797, when Bonaparte deposed the last doge.
The independent trading power fostered artists including Giorgione, Bellini and Titian.
Activists say 65 per cent of voters in the Veneto, including in historic Treviso, Vicenza and Verona, are in favour of independence. They cite dissatisfaction among the richer northern cities with Rome's perceived inefficiency and with tax revenue being diverted to the poorer south.
The populist Northern League - together with much of the region's electorate - sees the capital and the rest of the country as a drain on the local economy.
The party's leader in Veneto, Federico Caner, cites official figures that suggest this wealthy and industrialised region pays 20 billion ($32.6 billion) more in taxes to Rome than it receives in investment and services.
"We have our own identity, history and culture," he said. "Before Italy was a nation, Venice was the world's first democratic republic that had endured for 1000 years."
Voters will also be asked if an independent Venice should join the EU and Nato, and retain the euro.
- Independent