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In a rare English-language message believed to be from al Qaeda's No 2 leader, Ayman al-Zawahiri claimed Pakistan is now "virtually ruled from the American Embassy".
Zawahiri lists a litany of charges against Musharraf, who he says has betrayed Muslims by supporting the US after the September 11, 2001 attacks in its battle against the Taleban in Afghanistan.
"Pervez has insulted and compromised Pakistan's sovereignty by allowing the CIA and FBI to operate freely in Pakistan and arrest, interrogate, torture, deport and detain any person, whether Pakistani or not, for as long as they like, thus turning the Pakistani Army and security agencies into hunting dogs in the contemporary crusade," said the purported tape from Zawahiri.