While growing up, Mark and Scott Kelly supported different baseball teams. They also chose different universities. But, to the relief of Nasa scientists, that is about as distinct as the identical twin astronauts became.
Now the unlikely scenario of finding two indistinguishable spacemen is to be harnessed to the cause of science. Nasa has revealed that one will be put in a rocket and the other kept on the ground as part of a study on the effects of orbiting the Earth.
Scott, who is six minutes younger than his brother, will blast off in a year from now to spend 12 months aboard the International Space Station - twice the normal duration of a stay on the facility and the longest ever by an astronaut.
In the meantime, Mark, who retired as a Nasa commander after taking charge of the penultimate flight of the space shuttle programme in 2011, will be monitored on terra firma as the ultimate control subject for his brother.
The twins will be the subject of 10 separate investigations, costing a total of US$1.5 million and ranging from the effects of space travel on their digestive tracts to a study into how genes react as a result of being in orbit for a prolonged period.