The 29th of this month marks the centenary of the death of the explorer and his team, who all perished on his second trip - the Terra Nova expedition - to the Antarctic in 1912.
Ironically, the letter reveals his wife's optimism and her belief that he would return in triumph.
Other personal effects found on Scott's body and never before seen in public include an initialled case in red leather containing a picture of his wife and young son, Peter. The letters will be brought to life in a new ITV drama-documentary, Words of Captain Scott, to be broadcast in Britain on March 31, with Dougray Scott as Captain Scott.
The explorer's grandson, Falcon Scott, who inherited the letters from his father, Sir Peter Scott, a naturalist, said he decided to release them to mark the centenary of his grandfather's death.
"Despite revealing the contents, I've kept the actual letter because it's quite personal and I'm just not ready to put it into a museum just yet." he said.
"I think that my children have the right to make that choice during their lives. But the next best thing is to publicise what we have got and ensure the public do have access to it in some way."
- Independent