Thick black smoke billowing from the Little Saigon Market in Footscray has forced road closures and prompted a warning to residents to close doors and windows and turnoff airconditioners.
The MFB were called to the Nicholson St complex shortly after 6am local time.
More than 60 firefighters, three ladder platforms, two ultra-large pumpers and 12 pumpers are at the scene, still trying to bring the fire under control.