Schizophrenia linked to faulty gene - study

Scientists have made a breakthrough in understanding the biological basis of schizophrenia.

The findings could result in earlier diagnosis in children and young people, and lead to the development of new drugs and better treatment.

A study has found that a genetic defect in some people can trigger a dangerous increase in levels of a natural brain chemical called dopamine, which may lead to schizophrenia.

Although the discovery applies to only a small proportion of people who develop the illness, scientists who conducted the study believe it could result in a fundamental shift in the understanding of the condition.

"The hope is we will one day be able to identify the highest-risk groups and intervene early to prevent a lifetime of problems and suffering," says Allan Reiss, of Stanford University in California. "As we gain a better understanding of these disorders, we can design treatments that are more specific and effective."

About one in 100 people will suffer from schizophrenia at some time in their lives. It is characterised by changes in thoughts, perception and behaviour, and typically strikes people in their 20s or early 30s.

One in five makes a full recovery but an equal number need expensive, long-term treatment. The rest recover in part but may suffer relapses.

The general population has a 1 per cent chance of developing the illness. The risk increases to 10 per cent for the close relatives of a patient, and for identical twins rises to 47 per cent if one is already diagnosed.

The study, published in the journal Nature Neuroscience, investigated 24 children who suffered from a genetic mutation known as a deletion on one chromosome.

It is known that about one-third of children with this deletion to part of chromosome 22 will develop schizophrenia. The deletion occurs in one in 4000 births.

The study found one of the genes on the part of the chromosome that is missing is responsible for a protein that degrades dopamine, a critical chemical messenger, or "neurotransmitter", in the brain.

- INDEPENDENT