Embracing his identity as a corporate gadfly, Schiffrin's record of success with the New Press included the Pulitzer Prize-winning "Embracing Defeat" by John Dower and "The New Jim Crow" by Michelle Alexander. In his own books and interviews, Schiffrin argued that corporate control was incompatible with literature and threatened free expression.
That wasn't to say that Schiffrin's tastes were incompatible with readership. Pantheon, where his father Jacques was among the founders, married the avant-garde left and the mainstream. The two were held together by Schiffrin's belief that a good book will always find readers.
Schiffrin was born into a Jewish family in Paris on June 14, 1935. The Nazis marched into the city on his fifth birthday, and the following year his family fled to the United States. He began working at Pantheon shortly after Random House bought it in 1961.
Terkel, the late Chicago-based radio host and oral historian who was among Schiffrin's best-selling writers, once described Schiffrin as his "muse." But most of Pantheon's books, which tended to a leftist social advocacy that had gone out of style by the 1980s, reached a far narrower audience.
The Random House CEO at the time said he was "publishing a lot of books that no one wanted to read." Schiffrin was asked to cut back staff and titles. Instead, he resigned.
The response was unprecedented. Arthur Miller, Nadine Gordimer, and Amy Tan were among authors to sign an ad critical of Schiffrin's treatment. More than 200 writers protested outside Random House headquarters, including Kurt Vonnegut, E.L. Doctorow and Terkel.
Marilyn B. Young, a professor at New York University, was among the writers who left Pantheon along with Schiffrin, never really looking back.
"He was genuinely interested in what you were doing, in its subject matter, not just as a book to be packaged and sold," Young said. "There's an immediate and intense loyalty to Andre. Once you've worked with him, you never wanted to work with anyone else. It was an opening to the left of center without being sectarian in any way. It was an opening to new ideas and theories."
Schiffrin likened his new venture, the New Press, to public television and radio, and the imprint he founded in 1992 ultimately flourished, despite his grim predictions for the future of publishing.
"Now publishing is almost entirely a matter of profitability, meaning that if you want to publish something that is immediately profitable, it's very rare that it will turn out to be predicated on strong ideas, or dissident ideas," he told The White Review, an art and literary journal, in 2010.
Schiffrin is survived by his wife and two daughters.