Russia-US relations fell to a new post-Cold War low as the Obama Administration abandoned efforts to cooperate with Russia on ending the Syrian civil war and forming a common front against terrorists there, and Moscow suspended a landmark nuclear agreement.
The latter move, scuttling a deal the two countries signed in 2000 to dispose of their stocks of weapons-grade plutonium, was largely symbolic.
But it provided the Kremlin with an opportunity to cite a series of what it called "unfriendly actions" towards Russia - from Ukraine-related and human rights sanctions to the deployment of Nato forces in the Baltics.
The United States, the Russian Foreign Ministry said, has "done all it could to destroy the atmosphere encouraging cooperation".
Of far more immediate concern, the end of the Syria deal left the Administration with no apparent diplomatic options remaining to stop the carnage in Aleppo and beyond after the collapse of a short-lived ceasefire deal negotiated last month.