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Coronavirus has already prompted the industry to dial back exposure in Asia, where companies had a relatively small but growing presence.
But the Meraviglia incident - coupled with mounting cases of coronavirus in Italy - appeared to signal the potential for a broader disruption in bigger markets, exacerbating the hit to cruise stocks.
"It would be devastating to the cruise business if disruption extends from Asia to core markets like the Caribbean," Patrick Scholes, an analyst at SunTrust, said in an email.
Cozumel is the MSC Meraviglia's next scheduled port of call.
MSC Cruises, which says it doesn't have any evidence of coronavirus on the ship, said it was in touch with local health authorities in Mexico to ensure that their decision on disembarkation is factually based.
The company said its medical records show one case of seasonal flu in a crew member, who boarded the ship in Miami after travelling from Manila.
Earlier in the day, it appeared unclear what would happen upon arrival. A report from Mexico's Milenio said the ship's arrival in Cozumel had already been cancelled, citing a source in the port authority.
But Health Secretary Alejandra Aguirre Crespo - of Quintana Roo, the state where Cozumel is located - seemed to echo MSC's findings that the crew member in question had regular flu, not coronavirus.
The episode is the latest example of a cruise ship seemingly trapped at sea over coronavirus concerns, as governments seek to keep cases away from their shores. The incidents have hit consumer sentiment during peak bookings season, battered cruise stocks and prompted companies to reduce profit estimates for the year.
Until now, the showdowns over cruise ships have taken place in Asia and Europe. The Meraviglia debacle strikes much closer to home for the US and Latin America, where Brazil just confirmed the first coronavirus case.
- Bloomberg