"The region is moving in a very problematic direction," said Evans Revere, a former senior U.S. diplomat and East Asia specialist. "That's the result of territorial disputes, historical issues, long-standing rivalries and the inability of countries to put history behind them and move forward in improving relations."
Adding to this witches' brew of bickering in the region, Washington is grappling with the threat posed by an unpredictable North Korea. The deal the U.S. orchestrated with Iran to temporarily freeze its nuclear program, despite three decades of animosity, is a stark reminder of the impasse in negotiations with Pyongyang.
Unlike Iran, North Korea already has a nuclear bomb, and there's worrying evidence it is pressing ahead with weapons development.
Vice President Joe Biden will broach these issues when he travels to Japan, China and South Korea next week a trip to demonstrate that the top level of the administration remains focused on Asia.
The administration said that in Beijing, Biden will meet with Chinese leaders including President Xi Jinping and will voice concern about what it calls an emerging pattern of behavior by China that is unsettling to its neighbors. The vice president will also make clear the firm U.S. commitment to its allies and its desire for a lowering of tensions between China and Japan, the world's second- and third-largest economies.
Secretary of State John Kerry hasn't neglected the region, but his primary focus is on the Mideast and is likely to remain that way as he strives for the distant goals of an end to Syria's civil war, peace between Israelis and Palestinians and a comprehensive nuclear agreement with Iran after the current pact expires in six months.
U.S. domestic woes have contributed to a narrative that Asia is a secondary concern to the administration.
Obama was forced to cancel a four-nation trip to the region in October because of a partial U.S. government shutdown and threat of a debt default. He'll travel to Asia in April instead.
Obama made Asia a foreign policy priority when he took power in 2009 and has been particularly active in engaging China. Not known for the personal touch with foreign leaders, Obama sought to cultivate a relationship with new leader Xi when he met him in June at a California resort. That's part of a strategy to promote cooperation between the world's two largest economies and prevent their rivalry in the Asia-Pacific from spawning conflict.
But China's declaration of its East China Sea air defense zone will be viewed as unhelpful. It was rejected by Japan, South Korea and Taiwan and prompted quick expressions of deep U.S. concern that it could escalate tensions in the region.
"This really casts bit of a pall over efforts to improve (U.S.-China) relations," Revere said.
The U.S. said it would not change how it conducts military operations in the region and flew a pair of B-52 bombers through the zone Tuesday on what officials said was a long-planned training mission.
China's Defense Ministry said Wednesday it had detected and monitored the bombers. It said all aircraft flying through the zone would be monitored but made no mention of a threat to take "defensive emergency measures" against noncompliant aircraft that was included in an announcement Saturday.
Bonnie Glaser, a China specialist at the Center for Strategic and International Studies, expected Biden to raise the issue with civilian and military leaders in China. She said that while countries have a right to declare such a zone the U.S., South Korea and Japan all have them there will be concern about how China would enforce it.
"The question is how many times China will scramble their jets and against whom," she said.
State Department spokeswoman Jen Psaki said Wednesday China had announced the zone without prior consultation with other nations, although it overlaps existing air defense zones of both Japan and South Korea.
Most provocatively, the Chinese zone encompasses unoccupied but Japanese-administered islands that Japan calls Senkaku and China calls Diaoyu. Since Japan nationalized some of the islands a year ago, there's been a constant cat-and-mouse between the two nations' sea vessels and aircraft.
There's been no skirmish, although Japan accused China in January of locking targeting radar on a Japanese helicopter and frigate, which underscored the risks of a clash.