Pakistani officials were outraged by the bin Laden operation, which led to international suspicion that they had been harboring al-Qaida's founder. In their eyes, Afridi was a traitor who had collaborated with a foreign spy agency in an illegal operation on Pakistani soil.
Officials in Washington have called for Afridi to be released. On Thursday, State Department spokeswoman Marie Harf told journalists that Afridi's continued detention "sends exactly the wrong message."
"We hope this latest development leads to an outcome that reflects the fact that bringing Osama bin Laden to justice was clearly in Pakistan's interest as well as ours," Harf said.
The doctor was tried under the Frontier Crimes Regulations, or FCR, the set of laws that govern Pakistan's semiautonomous tribal region. Human rights organizations have criticized the FCR for not providing suspects the right to legal representation, to present material evidence, or to cross-examine witnesses. Verdicts are handled by a government official in consultation with a council of elders.
Anis, a commissioner tasked with enforcing the FCR, ruled that Afridi will be re-tried under the regulations by the top political official in Khyber, Shah said. Afridi was previously tried by the official's assistant.
The doctor's lawyer, Samiullah Khan, welcomed the decision to order a re-trial, saying: "I think it is a good achievement for us." He called the original decision to sentence Afridi to 33 years in prison "totally illegal."
But Khan said he was concerned about the decision to once again hold the trial under the FCR. He would rather the case be heard by a judge under Pakistan's normal legal system.
Khan said he had not been able to share the news with his client. The doctor has been held in prison with little contact with the outside world, and the lawyer said it had been months since he'd seen his client.
Afridi's brother Jamil Khan Afridi welcomed Thursday's ruling, but also demanded that the next trial not be held behind closed doors.
"He should be tried in an open court in the presence of media so that the world will know that my brother is innocent," the brother said. He called the allegations against Afridi "baseless."
The brother said the last time authorities allowed him to meet with Afridi was in August 2012, although the doctor's wife and children were allowed to see him on July 10.
It's unclear whether a re-trial will result in Afridi being released or simply receiving a reduced sentence. Freeing the doctor would remove a sore point between Pakistan and the U.S. at a time when relations have warmed relative to the dark days following the bin Laden raid. But the operation still causes consternation in Pakistan, and it could be politically difficult for the government if Afridi is released.
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Associated Press writers Rebecca Santana in Islamabad and Matthew Lee in Washington contributed to this report.