Obama will present the award Wednesday to the 2013 recipients, including Bill Clinton, Oprah Winfrey, the late astronaut Sally Ride, women's rights activist Gloria Steinem, baseball Hall of Famer Ernie Banks, country music singer Loretta Lynn and 10 others.
On Wednesday evening, Obama plans a speech on Kennedy's legacy of service with a dinner at the Smithsonian American History Museum attended by current and past recipients of the medal, including baseball's Hank Aaron, astronaut Buzz Aldrin, singer Aretha Franklin, economist Alan Greenspan, activist Jesse Jackson and former Secretary of State Henry Kissinger.
Kennedy's grandson, Jack Schlossberg, is to introduce Obama at the dinner. Other Kennedy members plan to attend, including Robert Kennedy's daughter Kathleen Kennedy Townsend and former diplomat Jean Kennedy Smith, a former medal winner and John Kennedy's last surviving sibling.
Friday marks 50 years to the day since Kennedy was killed by a gunman in Dallas. Obama will meet privately at the White House that day with leaders and volunteers from the Peace Corps program Kennedy established.
Details of Obama's plans were provided by the White House to The Associated Press.
President Harry Truman established an early version of the Medal of Freedom in 1945 to recognize those whose actions overseas advanced the national security of the United States or its allies, but it also could be bestowed by other top U.S. officials.
By executive order in February 1963, Kennedy made bestowing the Medal of Freedom a presidential privilege and expanded its scope to honor contributions to world peace, culture and other public interests.
After Kennedy's assassination, Johnson decided to move forward with the lunchtime ceremony in the State Dining Room and surprised the dignitaries in attendance by adding Kennedy and the recently deceased Pope John XXIII as posthumous recipients.
"In the shattering sequence of events that began 14 days ago, we encountered in its full horror man's capacity for hatred and destruction," Johnson said at the ceremony. "There is little we do not know of evil, but it is time to turn once more to the pursuits of honor and excellence and of achievement that have always marked the true direction of the American people."
Jacqueline Kennedy declined Johnson's plans to also award a medal to her. She watched from an anteroom as Attorney General Robert Kennedy accepted the medal on his brother's behalf. That afternoon, Mrs. Kennedy and her children moved out of the White House.
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