NSW is leading the charge against synthetic drugs, declaring a statewide ban and calling for the products to be outlawed across the country.
The move comes after Sydney teenager Henry Kwan fell to his death from the balcony of his home after taking a synthetic version of LSD bought on the internet and thinking he could fly.
Fair Trading Minister Anthony Roberts says NSW retailers who breach the 90-day interim ban on selling 18 synthetic drugs announced on Sunday will face fines of up to AU $1.1 million.
Products with names like Kronic, Circus Deluxe, Vortex Inferno and Montana Madness that mimic the effects of cannabis, cocaine and hallucinogens will be targeted.
"This week we'll be undertaking the largest operation ever seen in the commonwealth with respect to the crackdown on retailers selling these products that cause harm, and in some cases, death," Mr Roberts told reporters on Sunday.