The footage racked up millions of views within a few hours of being uploaded, with Facebook user Gps Erick commenting: "Are you sure that's traffic? Maybe they decorated the 405 with Christmas lights."
Dennis John Depew wrote: "It's called the 405 for a reason: It takes you '4 o' 5' hours to get anywhere."
"It's like the red and white blood cells flowing through the major arteries of the city. Pretty, wouldn't want to be in it," another wrote.
The footage was captured as tens of millions of Americans take to the roads, airports and railways for the Thanksgiving holiday, with 49 million expected to travel 80km or more, AP reports.
Last year, thousands of cars were left stranded on a motorway in China in what was dubbed "carmageddon"