At a few points, the audience booed Clinton and the stances she's taken.
"I do not receive many millions of dollars from Wall Street or the pharmaceutical industry or other powerful, wealthy interests in this country, and have not given speeches for hundreds of thousands of dollars to Wall Street," Sanders said, referring to money Clinton received between stepping down as Secretary of State and launching her presidential bid.
In the wake of his loss to Clinton in the Nevada caucuses, Sanders vowed he would be more aggressive in detailing the policy differences between the two, a posture he said did not violate his long-standing practice of running positive, issue-oriented campaigns.
Several of the differences Sanders cited were over legislation that advanced during the years that Bill Clinton was in the White House.
Clinton, meanwhile, yesterday expressed regret for 20-year-old comments about young, black "super-predators".
Clinton campaigned before largely African-American audiences across South Carolina.
Black voters, and her family's long association with them, are the linchpin of Clinton's strategy for winning the first Southern primary tomorrow. The winner will have a strong claim to momentum going into the next round of voting in Southern and Midwestern states with sizeable African-American populations - starting on Super Tuesday (Wednesday (NZT).
"My life's work has been about lifting up children and young people who've been let down by the system or by society, kids who never got the chance they deserved," Clinton told Washington Post columnist Jonathan Capehart.
Clinton was confronted with her own 1996 comments about gang crime during a videotaped encounter with a young African-American activist on Thursday, and the tense exchange hung over the Democratic contest yesterday, although Clinton did not address it during her public events.
Ashley Williams, a 23-year-old activist from Charlotte, interrupted Clinton during a private fundraiser in Charleston, South Carolina.
Williams stood and demanded an apology from Clinton for the high incarceration rate for black Americans, and told the Democratic candidate: "I am not a super-predator, Hillary Clinton."
In a written response yesterday to Capehart on the issue, Clinton said, "Looking back, I shouldn't have used those words, and I wouldn't use them today."
She also told NBC host Chuck Todd that her remarks had been "a poor choice of words".
-Bloomberg