But it later emerged two of the most seriously-injured victims had died in hospital.
Four-year-old in serious condition
The crash happened in the municipality of San Sebastian de Yali, around 185km north of the Nicaraguan capital Managua.
The victims included a 47-year-old woman named locally as Eneyda Torrez Zelaya, and her daughter Andrea Carolina Garcia Torrez, 8.
Another of those killed was an 84-year-old woman named as Reyna Isabel Olivas Montalvan.
A four-year-old boy is said to be in a serious condition in Victoria Mota Hospital in Jinotega, the nearest city to the crash scene.
Photos of those injured showed the victims with dozens of red welts all over their upper bodies.
Some were filmed arriving at hospital in the back of ambulances surrounded by anguished crowds of people.
Investigation under way
An investigation into the cause of the accident is ongoing, although initial reports point to the 22-year-old driver losing control of his vehicle because of mechanical faults.
Africanised bees, also known as Africanised honey bees and colloquially as the “killer bee”, is a hybrid of the western honey bee.
They are typically more defensive, reacting to disturbances faster and chasing people further than other varieties of honey bees.
They have killed some 1000 humans, with victims receiving 10 times more stings than from European honey bees.
The insects, which spread through South and North America after being introduced to Brazil in the 1950s and escaping quarantine, have also been blamed for the deaths of horses and other animals they have attacked.