In an email, Epps said she could not comment on her brother's post or the reason for the crew change and clarified that neither she nor anyone in her family created the petition.
Epps said that she did not have a medical condition or family problem that would have prevented her from participating in the mission, and that her overseas training in Russia and Kazakhstan had been successful.
Nasa likewise declined to comment about Henry Epps's post, but provided a statement saying: "Diversity and inclusion are integral to mission success at Nasa and we have a diverse astronaut corps reflective of that approach."
Last-minute crew changes are not unusual at Nasa. Apollo 13 pilot Ken Mattingly was famously pulled from his mission days before launch after being exposed to German measles. It's also common for Nasa to give limited explanations for these changes, which may involve private medical reasons or other sensitive information.
Epps, who has a PhD in aerospace engineering, was selected as a Nasa astronaut in 2009 after seven years of working for the CIA. In an interview with New York Magazine last year, after her historic assignment to the ISS crew was announced, Epps said she felt "a huge amount of responsibility".
Fourteen African American astronauts have flown in space, and several have visited the space station. In 2008, astronaut Leland Melvin was part of the space shuttle crew that delivered the Columbus science laboratory to the space station. But Epps would have been the first to serve on the ISS long term.
"As a steward, I want to do well with this honour," Epps said. "I want to make sure that young people know that this didn't happen overnight. There was a lot of work involved, and a lot of commitment and consistency. It is a daunting task to take on."
Alongside Epps, Auñón-Chancellor was one of 14 astronaut candidates selected out of some 3500 applicants for Nasa's 20th astronaut class in 2009. She has a medical degree and previously served as a surgeon and managed medical operations for a range of Nasa missions.
Auñón-Chancellor's selection was also history-making: She will be the first Hispanic woman to live on the space station.