"If you are still out there, Lisa, somewhere, I still love you, I still love you to bits."
Earlier this month, the WA government announced a A$1 million reward for information that leads to a conviction in Lisa's suspected homicide.
Flower said at the time of Lisa's disappearance, other girls had gone missing in WA.
"I did fear this happening, but at the same time I thought Collie was safe," she said.
"When Lisa first disappeared, I went into shock and ended up in the Collie Hospital in the middle of the night.
"I was screaming and could not stop myself. The night sister put me under a shower and left me there until I calmed down."
Since then, Flower said she had been in a "state of waiting for the other shoe to drop" for most of her life.
"I suppose in a lot of ways I've given up hope that I will ever know, and it's hard not to do that," she said.
"My only hope is after all this time that somebody is still alive that might know something because it's a long time ... a lot of things have changed."
Flower said she still struggled to talk too much about her daughter.
"I can't talk about Lisa very much, as it still hurts too much," she said.
"I have to stay in the present, so all the work I had to do to cope stays in place."
There have been many theories about what happened to Lisa, including that serial killer David Birnie was involved.
He took his own life in prison in 2005.