A bridge on a main highway linking Italy with France collapsed in the Italian port city of Genoa during a violent storm, sending vehicles plunging 45m into a heap of rubble.
Italy's leader says 22 people have been killed and 16 injured in a highway bridge collapse in Genoa and he fears that the final death toll may rise further.
Local media reported that a baby was one of the vitcims.
A huge section of the Morandi Bridge fell at midday (local time) over an industrial zone, sending tons of twisted steel and concrete on to warehouses below. Photos from the Italian news agency ANSA showed a massive gap between two sections of the bridge.
The head of Italy's civil protection agency, Angelo Borrelli, said 30-35 cars and three heavy trucks were on the 80m section of the bridge that collapsed.
Hundreds of firefighters and emergency officials were searching for survivors in the rubble with heavy equipment. Firefighters said at least two people were pulled alive from vehicles and taken by helicopter to a hospital.
Video of the collapse captured a man screaming: "Oh, God! Oh, God!" Other images showed a green truck that had stopped just short of the edge and the tyres of a tractor trailer in the rubble.
One witness said he saw the 50-year-old structure "wobbling" minutes before it gave way as dramatic footage showed it being struck by lightning seconds before it crumbled.
"It was just after 11.30 when we saw lightning strike the bridge and we saw it going down," eyewitness Pietro told Italy's Ansa news agency.
One unnamed witness said: "We heard an incredible roar and first we thought it was thunder very close by.
"We live about three miles from the bridge but we heard a crazy bang... We were very scared... Traffic went completely haywire and the city was paralysed."
Laurie Merchant, who was in Genoa at the time, told MailOnline: "The storm this morning was something else: very heavy rain and relentless. There was thunder like never before which sounded like a cannon. I was about five minutes from the bridge and I heard a loud crumbling when it went down.
"All you can hear in the city is the sirens of the emergency vehicles going non-stop from the bridge to the hospital.
"The air ambulance has been hovering most of the day. There are huge numbers of people outside the hospital and on the main shopping street there are two vans for people to donate blood."
A man who was under the highway bridge that collapsed in Italy calls it "a miracle" that he survived.
The middle-aged man tells local Italian TV that he was standing in front of his truck under the bridge in the city of Genoa when the structure collapsed Tuesday. He spoke in Italian as he was being filmed walking away from the disaster site but did not give his name.
He says the shockwave sent him flying over 10 meters (33 feet) into a wall, injuring his right shoulder and hip.
He says "I was in front of the truck, and flew away like everything else. Yes, I think it's a miracle. I don't know what to say. I'm out of words."
There was confusion over the death toll, which changed several times during the day.
Civil protection authorities said 20 were killed and 16 were injured, based on multiple verifications from the prefecture's office. But Genoa Mayor Marco Bucci told Sky TG24 that the number of dead was above 25 people and that 11 injured were pulled from the rubble. Two other officials earlier put the death toll at 22 with 13 injured but said it was expected to rise.
Borrelli told a news conference in Rome that all the victims appeared to all have been in vehicles that fell from the bridge.
The disaster occurred on a highway that connects Italy to France, and northern cities like Milan to the beaches of Liguria. The Morandi Bridge connects the A10 highway that goes toward the French Riviera and the A7 highway that continues north toward Milan. Inaugurated in 1967, it is just over 1km long.
The collapse came on the eve of a major Italian summer holiday on Wednesday called Ferragosto, which marks the religious feast of the Assumption of Mary. It's the high point of the season, when most businesses are closed and Italians head to the beaches or the mountains. That means traffic could have been heavier than usual on the Genoa highway.
The design of the bridge has been criticised in the past. Antonio Brencich, a professor specialising in reinforced concrete construction at the University of Genoa, called the span "a failure of engineering" in an interview in 2016.
"That bridge is wrong. Sooner or later it will have to be replaced. I do not know when. But there will be a time when the cost of maintenance will be higher than a replacement," he told Italian media Primocanale.
Borrelli said highway engineers were checking other parts of the bridge and that some areas were being evacuated as a precaution. He said they were still trying to figure out the cause of the collapse.
"You can see there are very big portions of the bridge [that collapsed]. We need to remove all of the rubble to ascertain that all of the people have been reached."
He said more than 280 rescue workers and dogs units were on the scene.
"Operations are ongoing to extract people imprisoned below parts of the bridge and twisted metal."
Transportation Minister Danilo Toninelli called the collapse "an enormous tragedy", adding that if negligence played a role, "whoever made a mistake must pay".
Toninelli said the company that has the concession to operate that section of highway said its maintenance on the bridge was up to date and no work was being done at the time of the collapse. But he added that they were about to launch a €20 million ($34.5m) bidding process for significant safety work on the bridge.
"There has not been sufficient maintenance and checks, and safety work for many bridges and viaducts and bridges in Italy constructed — almost all — during the 1960s."
Since getting his job two months ago, Toninelli said he has asked for updates on the state of all bridges and viaducts in Italy. Many are operated by outside contractors.
French President Emmanuel Macron, meanwhile, offered his country's help in a phone call with Italian Prime Minister Giuseppe Conte, who was expected to travel to Genoa later in the day.
It was the second deadly disaster on an Italian highway in as many weeks.
On August 6, a tanker truck carrying a highly flammable gas exploded after rear-ending a stopped truck and getting hit from behind near the northern city of Bologna. The accident killed one person, injured dozens and blew apart a section of a raised eight-lane highway.