Scientists are closing in on a way to help young boys undergoing cancer treatment to preserve their future fertility — and the proof is the first monkey born from the experimental technology.
More and more people are surviving childhood cancer, but nearly one in three will be left infertile from the chemotherapy or radiation that helped save their life. When young adults are diagnosed with cancer, they can freeze sperm, eggs or embryos ahead of treatment. But children diagnosed before puberty can't do that because they're not yet producing mature eggs or sperm.
"Fertility issues for kids with cancer were ignored" for years, said University of Pittsburgh reproductive scientist Kyle Orwig.
Orwig's team reported a key advance yesterday: First, they froze a bit of testicular tissue from a monkey that hadn't yet reached puberty. Later, they used it to produce sperm that, through a monkey version of IVF, led to the birth of a healthy female monkey named Grady.
The technique worked well enough that human testing should begin in the next few years, Orwig said.