The U.N. High Commissioner for Refugees Antonio Guterres expressed concern that Syrians fleeing conflict have sought to reach Europe by such a perilous route, calling it "inhumane."
"They escaped bullets and bombs only to perish before they could ever claim asylum," he said, adding that there had been reports that the vessel had been fired on shortly after departing Zwara, Libya.
U.N. Secretary General Ban-Ki-moon called for action to prevent future tragedies "that places the vulnerability and human rights of migrants at the center," while Pope Francis lamented that "too often we are blinded by our comfortable lives, and refuse to see those dying at our doorstep."
The boat in Maltese waters capsized afternoon about 65 miles (105 kilometers) southeast of Lampedusa, in waters where Malta has search and rescue responsibilities.
A joint Italian-Malta operation rescued nearly 200 people after the Italian Coast Guard received a distress call via satellite phone from the boat and a Maltese aircraft sighted the capsized boat with numerous people in the water. At least 34 people died, while 146 survivors were brought to Malta.
The victims included a 3-year-old boy whose body was found floating in the sea more than a day after the boat capsized, said Silvio Scerri, the chief of staff at Malta's Home Affairs Ministry.
The U.N. refugee agency said survivors claim up to 400 people were on board. Search operations were still under way.
Other survivors, 56 in all, who were not in immediate need of medical attention were heading to Sicily on board an Italian frigate.
Italian Naval spokesman Cmdr. Marco Maccaroni said also rescued some 180 people from other boats in the same area overnight another indication of the relentless flows of migrants braving the Mediterranean.
"The flows have never stopped, especially over the summer months," Maccaroni said. "The two accidents in such a short period have raised the attention of the public, but the tensions have been going on all summer."
Some 30,100 migrants arrived in Italy and Malta in the first nine months of 2013, compared with 15,000 in all of 2012, according to the U.N. refugee agency.
At least 70,000 Syrians are registered in Egypt as refugees. Many, including thousands of Palestinians who also fled the war in Syria, are not registered and use the country as a stopover before making the perilous sea trip to Europe.
Just 155 people survived in last week's shipwreck off Lampedusa. Caskets carrying the bodies of 80 of the 339 people, mostly Eritreans, who died were boarded on a ferry in Lampedusa to be transported to Sicily, where the victims of last week's shipwreck are to be buried.
"Urgent measures must be adopted to open humanitarian corridors. There is no time to lose," said Francesco Rocca, the president of the Italian Red Cross, emphasizing that people escaping war and repression must be given a safe route of escape. "In this way it would hit also the traffickers and we could stop this ceaseless massacre."
Italy's integration minister, Cecile Kyenge, called for increased patrols to stop smugglers.
"Behind these tragedies, as the dramatic instability of African countries increases, there are human traffickers who are enriching themselves on the backs of people who are fleeing war and hunger," said the Congolese-borne Kyenge.
Europe, an Italian observatory that tracks migrant deaths reported by the media, says about 6,450 people died in the Strait of Sicily where Lampedusa is located between 1994 and 2012. Often ships disappear at sea, leaving no way to verify the deaths.
- AP