From there, the First Lady is asked about the state of her marriage, her husband's infidelity and her views on the #MeToo movement.
"Can women in the #MeToo movement call you a supporter," asks Llamas in a preview obtained by DailyMail.com.
"You're not the first first lady to have to deal with your husband's infidelities, has this put a strain on your marriage?" he later asks the First Lady.
The preview ends with him asking about "the jacket", which the First Lady wore soon after her husband's Justice Department enacted an order which allowed parents and their children to be separated at the border.
On a visit to one of the facilities housing those children, The First Lady wore a Zara jackets which read: "I Really Don't Care Do You?"
People, it turned out, did in fact care.
And lastly, Llamas asks the third Mrs. Trump what the biggest misconception is about her.
The First Lady sat down with Llamas while the two were in Africa on her first solo foreign trip.
It has been over a year since Melania gave an interview with a major network, and almost all of her appearances on television have been by her husband's side.
Last June, the First Lady spoke with "Fox & Friends" host Ainsley Earhardt in a segment that was filmed days before during the annual Congressional picnic, revealing that she could not be happier just two weeks after moving into the White House with son Barron.
"We are enjoying it very much," Melania said of her time thus far at 1600 Pennsylvania Avenue.
When asked how her then 11-year-old son was handling the move, Melania said: "He loves it, yes all settled. He loves it here."
"I'm so busy and we're doing so many great stuff. So it's really special place and I love it here," said Melania, who was born in Slovenia.
She became a permanent resident of the United States back in 2001, and five years later she was able to obtain her citizenship after marrying Donald Trump.
Melania, who is only the second first lady to have been born outside the country, also spoke a bit about putting together her first Congressional picnic.
"Tonight, it's a great picnic, Congressional picnic with all of us getting together," said Melania.
"It's New York City team. And we have carousel and great stuff outside."
That interview with "Fox & Friends" was far briefer and toned down than her chat with ABC, and was filmed in the largely nondescript Map Room of the White House.
It was also more Melania making a cameo in the interview, with a majority of the time being taken up by President Trump as he talked about healthcare, James Comey and what he believes are his biggest accomplishments since taking office.
The First Lady, who was asked just four questions during the 20-minute interview, smiled and nodded along approvingly as her husband spoke.