A meeting of Latin America's leaders, to be attended by US President Barack Obama, will hear serving heads of state admit that the war on drugs has been a failure and that alternatives to prohibition must be found.
The Summit of the Americas, to be held at Cartagena, Colombia, next weekend is being seen by foreign policy experts as a watershed in the redrafting of global drugs policy in favour of a more liberalised approach.
Otto Perez Molina, the President of Guatemala, who as the former head of his country's military intelligence service experienced the power of drug cartels at close hand, is pushing his fellow Latin American leaders to use the summit to endorse a new regional security plan that would see an end to prohibition.
Perez Molina wrote in the Observer: "The prohibition paradigm that inspires mainstream global drug policy today is based on a false premise: that global drug markets can be eradicated."
Perez Molina concedes that moving beyond prohibition is problematic.