"From the start of this year his health wasn't so good, but until then he'd drop into the hospital every so often to conduct exams and talk with patients," a hospital spokeswoman said.
In 1954, Hinohara introduced Japan's "human dry-dock" system of comprehensive annual physical exams, which was part of the preventive medical system and said to contribute to Japan's longevity.
Hinohara was an early advocate for healthier living and released 75 books on ways to stave off the ills of ageing. One book became bestseller on living well which he wrote at the age of 101. He was also a popular guest on Japanese television.
He once described a lifestyle that included orange juice with olive oil for breakfast and said that energy comes from feeling good, not fixed rules about living.
"We all remember how as children, when we were having fun, we often forgot to eat or sleep," he was quoted as saying.
"I believe we can keep that attitude as adults - it's best not to tire the body with too many rules such as lunchtime and bedtime."