The zoo was closed Saturday as officials tried to discover how the feline escaped and grief counsellors were brought in for traumatised staff. The zoo planned to reopen at 10 a.m. Sunday.
But the incident was certain to raise questions about the dangers of caging apex, or top, predators that have evolved to hunt and kill, and will quickly pounce on prey animals -- or humans - if safeguards break down.
In the spring of 2017, a British zookeeper was mauled after being trapped in the Hamerton Park Zoo's tiger enclosure with at least one of the big cats.
Horrified witnesses said they could see zookeepers sprinting to the edge of the tiger enclosure, throwing pieces of meat as an unsuccessful distraction.
In 2016, zookeeper Stacey Konwiser, 38, was killed while preparing the "night house" at the Palm Beach Zoo. The house is where the animals are cleaned and fed, then boarded overnight.
Also that year, at Beijing Safari World, a woman was injured and her mother killed after the younger woman got out of their car and was dragged off by a tiger.
Such breakdowns, experts have told The Washington Post, don't happen only at shoddy zoos with slapdash animal-care practices.
"These accidents happen, you know, on some kind of a recurring basis around the world," said Doug Cress, CEO of the World Association of Zoos and Aquariums. "And it's because you're dealing with animals that, at their genetic core, are built differently than we might like them to be. They are designed to be wild animals."
Joel Hamilton, the Audubon Zoo's vice president and animal curator, echoed that sentiment when asked whether there was something particularly aggressive about Valerio.
"He's a young male jaguar," Hamilton said. "He was doing what jaguars do. Certainly his behaviour wasn't out of the ordinary for that kind of an animal."
The zoo, originated from a bird habitat built in 1916, is a "58-acre jewel ranking among the US's best zoos," according to the Audubon Nature Institute, which oversees the zoo and other properties. The zoo is in Uptown New Orleans between Audubon Park and the Mississippi River.
Ron Forman, the zoo's president and chief executive officer, said the series of attacks was the worst in the zoo's history but told the public the Audubon Zoo was still safe.
"The zoo, it's been here for 100 years," Forman said. "In that time period, we've had over 100 million visitors to the zoo. We've never had an incident like that before. So I think statistically there's nothing to worry about the safety of coming to the zoo."