However, last month Ms Milne underwent a life-changing operation to fit cochlear implants.
Following the procedure, she faced a four-week wait for medics to switch on the implants to see if the operation had been a success.
Hearing for first time, a video capturing the switch-on shows Ms Milne breaking down as she tells her doctor her own voice sounds "very, very strange", before adding: "Wow, it is absolutely amazing."
The doctor tells the 40-year-old, from Gateshead: "It is a big, big, life-changing day.
"It is such a huge thing you have just achieved, you should be really proud of yourself."
Ms Milne said the switch-on has been the "most emotional and overwhelming experience" of her life.
She said: "I'm still in shock now. I have to learn to recognise what these sounds are as I build a sound library in my brain.
"Hearing things for the first time is so emotional from the ping of a light switch to running water.
"I can't stop crying and I can already foresee how it's going to be life changing."
"I'm so happy. Over the last 48 hours hearing someone laughing behind me, the birds twittering and just being with friends... they didn't have to tap my arm to get my attention which a massive leap."
Since she was diagnosed as deaf, Ms Milne has made it her mission to mentor others living with Usher Syndrome.
She added: "Being deaf was just who I was. Unfortunately when I became registered blind things changed dramatically and for the first time being deaf became increasingly difficult."
The breathtaking moment Ms Milne's implants were switched on was captured on video and shared by Ms Milne's friend Tremayne Crossley.
Moved by her courage Mr Crossley applied for Ms Milne to appear on DJ Lauren Laverne's BBC 6music radio feature Memory Tape.
His application said: "Jo has recently had a bilateral cochlear implant in an attempt to restore her hearing, this is being gradually switched on over five sessions.
"The volume has to be increased slowly to allow the brain to adjust to the new information coming from the ears.
"Jo told me about a guy who went grey over a one month period due to the shock of hearing how noisy the world actually is.
"It was with this in mind that Jo asked me to put a playlist of songs together, songs that I thought she needed to hear or that would form an 'Introduction To Music' playlist.
"I said it would be an absolute privilege but when I sat down to start I realised how monumentally difficult it would be, and what a responsibility."
Mr Crossley chose a song from each year of Ms Milne's life treating her to Paul McCartney's Silly Love Songs, Kate Bush Running Up That Hill (A Deal With God), Prince's When Dove's Cry, Tracy Chapman Fast Car, Maps by the Yeah Yeah Yeahs and Radiohead's Jigsaw Falling Into Place.
Taking to Twitter yesterday Miss Laverne told her 300,000 followers how Ms Milne's story had moved her crew to tears.
She tweeted: "Just watched a video of today's #MemoryTape recipient having her cochlear implant turned on and hearing for the first time. Studio in floods."
Hearing the moving feature, writer Caitlin Moran tweeted: "@NadiaShireen @BBC6MorningShow @laurenlaverne You might as well call this the 'Crying Uncontrollably At The Amazingness of Life' Tape."
Listener Ingrid Bronsgeest said: "You do bring some magic to peoples lives @BBC6Music that #MemoryTape story is amazing. Sooo emotional but happy tears too.x"
- Daily Mail