The U.S. Agency for International Development's budget would drop around 11 percent to $1.4 billion, while the State Department's funding level for foreign government assistance would fall by a quarter to $17.3 billion.
Tough conditions would be attached on aid to Afghanistan, Egypt, Pakistan and the Palestinians.
And Republicans are seeking again to block U.S. funds to any U.N. body or international family-planning group that may be involved in abortion, a change that the Senate has knocked down several times since Obama overturned the policy of President George W. Bush.
Much in the bill is unlikely to ever become law. Since leaving the Senate for his State Department post, Secretary of State John Kerry has repeatedly made the case that foreign assistance programs represent less than 1 percent of the federal budget, far less than the impression given by some lawmakers. The White House, too, opposes extreme cuts to foreign operations.
Like other agencies, the State Department has suffered from the across-the-board automatic spending reductions that went into effect earlier this year. This has forced the United States to cut $2.6 billion in global humanitarian aid, security funds and other international programs in some of the world's most unstable regions.