The stunning video is made all the more amazing because of the views of Earth and space through the windows of the ISS. The lyrics are also perfectly fitting.
"Here I am, sitting in a tin can, far above the world," Hadfield sings. "Planet Earth is blue ... and there's nothing left to do."
The video was mixed with the help of the Canadian Space Agency and features modified lyrics. "Ground control to Major Tom, lock your Soyuz hatch and put your helmet on," he sings. Hadfield is due to return aboard a Russian Soyuz space capsule that will land in Kazakhstan.
The 53-year-old former fighter pilot has about 790,000 followers on Twitter.
- additional reporting AAP