Many high-speed trains - including the renowned TGV service - were cancelled between Paris and other French cities in yesterday's opening salvo. Commuter train service within the capital was also suspended. And the Eurostar, connecting Paris with London, cancelled some runs through the English Channel tunnel.
Meanwhile, striking air traffic controllers forced the grounding of many short-haul flights at the Paris-area airports of Orly, Beauvais and Charles de Gaulle. Air travel disruption was expected to worsen today. Air France said that 30 per cent of long-haul flights would be affected, as would 20 per cent of short-haul flights.
Teachers, nurses and other workers also joined the strike. Some schools across the country were forced to close.
So far, Macron has been spared the kind of devastating strikes that have unravelled previous French governments.
The public-sector plans - which still need parliamentary approval - may prove to be a different story.
Macron seeks to forge ahead with these changes without the same level of calculated exchange with labour leaders as he engaged in ahead of the first round of labour revisions.
Elisabeth Borne, Macron's Transport Minister, defended the labour plans as crucial to ensure the strength and survival of France's state-owned railway company.
"This is a necessary, indispensable reform," Borne said, appearing on France's BFM TV. "My hope is not a test of strength; my hope is for negotiations."
But these changes - particularly with regard to the railways - strike at the heart of a system that has long been a model of the French state's collective commitments, both to transport and to those who run it.
Railway workers have long enjoyed expansive benefits, including generous pensions and, for some employees, the option of retirement at age 52, a full decade before the official retirement age of 62.
These benefits stem from an era when the job entailed manual labour, including the shovelling of coal - a time Macron has said is long gone.
"How old are you?" the young President responded to a railway worker at an agricultural fair last month, when asked about the proposals. "You do not have the same work rhythm as my grandfather, who was a railway man," Macron added. Macron's grandfather, Andre Macron, worked for France's state-owned railway company in the northeastern Somme region.
Political scientists see this as a watershed moment that could determine the future of the French welfare system in a time when Macron has already succeeded in bringing France slightly closer to Anglo-American visions of the state.
"If the Government succeeds in revising the legal status of the railway and other workers, it's really the end of an era," said Gerard Grunberg, an expert on the French political left and an emeritus professor at Sciences Po in Paris.
In the past, governments have quickly backed down in the face of massive protests.
In 1995, the centre-right Government of Alain Juppe, the Prime Minister of then-President Jacques Chirac, withdrew proposals to overhaul railway pensions after a strike brought the country to a standstill.
Union leaders are threatening much the same this year, said Jean-Marc Canon, secretary general of UGFF-CGT, a large public-sector union.
There is also symbolism at work. Yesterday marked the 50th anniversary of a 1968 student uprising that grew into the largest public protest in modern French history.
"Either they listen to us and it will have been just a warning shot," Canon said on French radio. "Or they don't listen to us and then, let me tell you that public-sector workers are very mobilised."
The question is whom the French will blame when the inevitable disruptions to public life occur, Grunberg said. Opinion polls suggest most French voters agree with Macron's proposals, but few French citizens will be unaffected by the planned strikes, which have yet to take their full toll.