Three people in Victoria have been hospitalised with Japanese encephalitis (JE) virus.
It comes after the disease was detected in several piggeries across New South Wales, Queensland and Victoria last week.
Four people have since contracted the virus requiring hospitalisation, though one was later discharged. It is believed these are the first cases to ever be reported in Victoria.
A spokesman for Victorian Department of Health said the four people had been exposed to mosquitoes.
JE virus is spread by mosquitoes passing the disease between pigs to humans.