Lens mayor Sylvain Robert is leading a campaign for the Mona Lisa to be exhibited temporarily at the Louvre-Lens, which is overlooked by slag heaps beside red-brick terraced houses and a chip shop.
Supporters of the local football club held up a huge banner with a picture of the Mona Lisa at a match last month, with a slogan reading: "Mona Lisa, the hearts of the people of Lens are beating for you."
Many townspeople hope that struggling local businesses will benefit from visitors who come to see the work. Nyssen said: "Cultural offerings exist. Why would they be confined to certain places and not accessible everywhere for all to enjoy?"
She also said care would be taken to preserve the prize exhibit.
Didier Rykner, an art historian, said it would be "irresponsible and extremely dangerous" to subject it to further travel. "It is extremely fragile. The wood panel it is painted on is extremely thin and there is a crack, which if it widened would damage it irreversibly."
The painting has not been seen outside the Louvre since 1974, when it was displayed in Tokyo and a woman tried to spray it with red paint. Luckily, it was protected by its bulletproof enclosure.