An Ethiopian Airlines flight crashed shortly after takeoff from the capital killing all 157 thought to be on board, according to statements from the airline and the state broadcaster.
There were no immediate details on what caused the crash of the Boeing 737-8 MAX plane, which was new and had been delivered to the airline in November.
The state-owned Ethiopian Airlines, widely considered the best-managed airline in Africa, calls itself Africa's largest carrier and has ambitions of becoming the gateway to the continent.
The airline's statement said 149 passengers and eight crew members were thought to be on the plane that crashed six minutes after departing Addis Ababa on its way to Kenya's capital. The crash occurred around Bishoftu, or Debre Zeit, some 50 kilometers (31 miles) south of Addis Ababa, at 8:44 a.m. local time.
While the airline said "search and rescue operations are in progress and we have no confirmed information about survivors or any possible casualties," a separate statement by the Ethiopian prime minister's office offered its "deepest condolences" to families.