They were married in Boston in August, a pair who fell in love and shared a passion for running.
On Tuesday, watching the Boston Marathon - a race one had run before - the couple each lost a leg after one of the two explosions that killed three and wounded dozens more.
Patrick and Jessica Downes each "sustained amputations below the left knee", according to an email sent to friends.
It said Patrick had a successful operation yesterday and was out of the intensive care unit. Jessica was in surgery and might be in danger of losing her remaining foot.
A page hosted by GiveForward.com, which helps users create fundraising sites, was established to raise money that will go towards the couple's medical bills and related costs.