Victoria has recorded 410 new cases and 21 new deaths - marking the state's deadliest ever day and another increase in cases.
The death toll is an increase from 19 deaths recorded on both Monday and Tuesday. The new figures mean 267 Victorians have died since the beginning of the pandemic and 249 have died since May.
Case numbers have also risen again. Victoria recorded 331 new cases on Tuesday. There were 322 new cases recorded on Monday.
The state is marked down for at least five more weeks of tough lockdown rules, and Daniel Andrews says that there's no guarantee even that will work.