Residents of neither city are as likely to be victims as in Detroit, however, where 386 people were murdered last year.
That is one for every 1832 locals, meaning a resident of Detroit is three times as likely to be murdered as one in Chicago.
Across the US, violent crime increased marginally after a decade of decline and guns were used in 70 per cent of murders.
In Chicago's South Side, the dangers were all too clear on the first day back at school last month as parents and escorts walked their children alongside specially-designated "safe passage" corridors.
Several hundred newly-hired security officers in bright neon vests joined armed police officers to guard roads running through gang boundaries, past derelict houses and abandoned plots, as pupils as young as four were escorted to school through urban war-zones along 53 new routes marked with bright yellow "safe passage" signs.
The programme was started in 2009 in the wake of the killing of a 16-year-old boy after he left his South Side high school one afternoon.
Rahm Emanuel, the city's mayor and Obama's former chief of staff, has ramped it up significantly this year in response to a spate of killings of children caught up in the city's violence.
He called the overwhelming security presence an "all-hands-on-deck" operation. In a murder that shocked the nation, Hadiya Pendleton, 15, was shot dead days after she performed at a presidential inauguration celebration for Obama in Washington in January. She had previously recorded an anti-gang video.
Other notorious killings have included a seven-year-old girl shot dead last summer as she stood at her mother's street-side sweet stand, and a six-month-old baby girl who was killed when a gang member opened fire on her father.
A candlelight vigil was held this week honouring police officers killed in the line of duty. Hundreds filled Gold Star Memorial Park, where the names of 567 were read out.
Even as the new statistics starkly illustrated how the city is plagued by violence, Mr Emanuel was this week touting some hopeful signs. Murders in Chicago were down to 286 from 366 for the same period in 2012, though still marginally up from 278 in 2011.
The murder rate is down 22 per cent, and down 45 per cent in the 20 neighbourhoods targeted since February for additional policing.