The destruction mission could include smashing mixing equipment with sledgehammers, blowing up delivery missiles, driving tanks over empty shells or filling them with concrete, and running machines without lubricant so they seize up and become inoperable.
Some of the inspectors will be double-checking Syria's initial disclosure of what weapons and chemical precursors it has and where they are located. Others will begin planning the logistics for visits to every site where chemicals or weapons are reported to be stored.
Within a week, a second group of inspectors is scheduled to arrive and form teams that will fan out to individual locations.
The inspectors' mission was born out of a deadly chemical attack on opposition-held suburbs of Damascus on Aug. 21. The U.S. and its allies accuse the Syrian government of being responsible, while Damascus blames the rebels.
The chemical attack prompted the Obama administration to threaten punitive missile strikes against the Assad regime, touching off weeks of frantic diplomacy that ended with Friday's U.N. resolution.
The resolution also endorsed a roadmap for political transition in Syria adopted by key nations in June 2012, and it called for an international peace conference in Geneva to be convened "as soon as possible" to implement it.
The Geneva negotiations have been repeatedly delayed for months, with neither the Syrian regime nor the opposition showing much interest in attending while the war on the ground remains deadlocked. Disagreements also have flared repeatedly over who should take part in the talks.
Efforts to bring the sides to the table received another blow over the weekend when Syria's foreign minister said the government won't talk with the main Western-backed opposition group, the Syrian National Coalition.
Russia, a close ally of Syria, tried to smooth things over Tuesday, with Foreign Minister Sergey Lavrov saying that "reasonable" Syrian rebels could participate. Speaking to reporters in Moscow, Lavrov said Western powers should help encourage rebels who don't harbor "extremist or terrorist views" to take part.
The rebel movement on the ground also is riven by fissures that have burst to the fore in recent months, as Islamic extremist rebel brigades associated with al-Qaida battle more mainstream rebel factions nominally linked to the Western-backed Free Syrian Army.
Also Tuesday, a Syrian activist group that tracks the conflict said that more than 115,000 people have been killed in the revolt. The tally from the Britain-based Syrian Observatory for Human Rights includes around 29,000 regime troops, 18,000 pro-government militiamen, and some 23,000 rebels.
In July, the U.N. put the Syrian death toll at more than 100,000, but it has not updated its numbers since then.
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Associated Press writer Laura Mills in Moscow contributed to this report.