Up to 50 UK Labour MPs have revolted against leader Jeremy Corbyn and voted to back airstrikes against Isis targets in Syria.
The vote ended at 397-223 to launch airstrikes.
Sky News reports that jets have already taken off from Cyprus and are heading to the area of operation where they will begin airstrikes overnight.
Foreign Secretary Philip Hammond said the operation would begin "very quickly", Foreign Secretary Philip Hammond.
Corbyn called the plan for strikes an "ill-fated twist in never-ending war on terror", but lost the support of his caucus.