In the U.S., Clinton cast the economic uncertainty as a reason America needs "calm, steady, experienced leadership" in the Oval Office " a knock on her often unpredictable and politically inexperienced Republican rival. Clinton aides also highlighted Trump's assertion Friday that a weaker pound would make his Scottish golf course more attractive to visitors.
"Donald Trump actively rooted for this outcome and he's rooting for the economic turmoil in its wake," said Jake Sullivan, Clinton's senior policy adviser.
Other Democrats, openly anxious, warned that the party should not underestimate the willingness of angry American voters to choose a more uncertain path in November and side with Trump.
"It's a timely big splash of cold water the face of Democrats," said Ron Kirk, the former Democratic mayor of Dallas and U.S. trade representative for President Barack Obama.
Democratic operative Lynda Tran said that if U.S. voters are indeed seeking a broad political overhaul in November, Clinton will be "at a major disadvantage."
"Having spent the last three decades of her life in public service, in the public eye and being a core part of the policies and the administrations that have brought us to where we are right now, it's very difficult for her to grab the mantle of change," Tran said of the former secretary of state, senator and first lady.
The British referendum comes as Trump tries to rebound from one of the worst stretches of his campaign. He's struggled to raise money and build a robust organization for the general election, and this week he shook up his operation by firing campaign manager Corey Lewandowski.
But for some Republicans, the outcome in Britain was a reminder that despite Trump's shortcomings, he may be the candidate most attuned to voters " an intangible that campaign cash can't buy.
"Brexit is a wakeup call for the Clinton team," said Scott Reed, chief strategist for the U.S. Chamber of Commerce. "The status quo won't work this cycle."
The referendum was fueled by support from white, working class voters from outside Britain's population centers " a similar profile of Trump's supporters. The biggest challenge for Trump will be broadening his base and overcoming his negative standing with minorities and women.
Unlike in Britain, where the referendum was decided on the basis on a national popular vote, the American election is determined on a state-by-state basis, with many of the most politically powerful states also being the most diverse.
But Jerry Spaulding, a farmer from Gilmanton, New Hampshire, who plans to vote for Trump in November, said he wouldn't be surprised if the breadth of Trump's support is broader that it may look in public opinion polls.
"I do think you're going to see a lot of people coming out of the woodwork like they did in Britain," Spaulding said.
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