"They knew about it, they were architects of it, they planned it, they sought funding for it, they kept it under the radar. Hopkins provided syphilitic rabbits that were used to inject individuals with syphilis."
The suit alleges that experiments were carried out on women, soldiers and patients with mental health issues. The tests involved allowing participants to have sex with infected women or by using needles to open wounds that could be infected.
Children were also included in the study but not deliberately exposed to the diseases.
Some plaintiffs attempted to sue US government officials in 2011, but the case was thrown out on the basis that the Government could not be held accountable for what was committed in another country. It apologised to victims in 2010 for the "reprehensible research" conducted "under the guise of public health".
Some plaintiffs attempted to sue US government officials in 2011, but the case was thrown out on the basis that the Government could not be held accountable for acts committed in another country.
In a statement, John Hopkins said: "Johns Hopkins did not initiate, pay for, direct or conduct the study in Guatemala. No non-profit university or hospital has ever been held liable for a study conducted by the US Government.
"The plaintiffs' essential claim in this case is that prominent Johns Hopkins faculty members' participation on a government committee that reviewed funding applications was tantamount to conducting the research itself and that therefore Johns Hopkins should be held liable. Neither assertion is true.
"A class action lawsuit seeking to hold federal officials responsible for the Guatemala study has been filed and dismissed. US District Court Judge Reggie Walton dismissed that action in 2012 and stated that the pleas of victims for relief are more appropriately directed to the political branches of the federal government.
"For more than half a century since the time of the Guatemala study, scholars, ethicists and clinicians have worked with government officials to establish rigorous ethical standards for human research. Johns Hopkins welcomes bioethical inquiry into the US Government's Guatemala study and its legacy. Plaintiffs' legal claims are not supported by the facts.
In a written statement, the Rockefeller Foundation called the research "morally repugnant," and said it agrees that the US government owes reparations to victims and their families. However, it says the foundation "did not design, fund, or manage any of these experiments, and had absolutely no knowledge of them," and will oppose the lawsuit.
- Independent, with additional reporting by the Associated Press