The famous part of Anaheim is, of course, Disneyland, aka "The Happiest Place on Earth". By virtue of reputation alone it's a must-visit destination for many families with its original rides (think Mad Tea Party spinning tea cups and Space Mountain) as well as more elaborate modern rides and firework displays. Schedule in Knott's Berry Farm, too, with its Old West theme and rides that out-do Disneyland's for thrills.
The canyon is sensationally beautiful to look at, but nothing beats going down into the canyon to appreciate the scale. Kids 10 years and older can ride a mule 700m down the North Kaibab Trail. Those four and older can do the Grand Canyon Skywalk.