The pump-style dispensers of shampoo, conditioner and body wash have already replaced minis at a range of Intercontinental Hotel Group properties and Marriott hotels across North America.
Marriott will be scrapping the complimentary minis at 1500 North American hotels by January.
The fixed dispensers have already been a staple in some hotels in Australia and the Europe — but the hotel giants may have started a trend that sweeps the rest of the globe.
The hotel chains said the decision was a move to cut down on plastic waste and save money.
Billions of half-full bottles get thrown away every year, the Wall Street Journal reported. When Marriott's switch to refillable dispensers is complete in January, it may spare about 170,000 kilograms of plastic from ending up in landfill a year.
But not everyone is happy.
Dennis Lennox, a strategic communications consultant from Detroit who spends more than 200 nights a year in hotels, told the Journal he collected the mini toiletries to donate to a homeless shelter.
"What's next, getting rid of the packs of coffee and making us scoop out of a can?" he said.
"I think it's cheap, incredibly cheap."
Anne Smith is the vice president of brand management and design for small hotel chain Choice Hotels, which will continue using the bathroom minis.
She said guests didn't always trust the contents of the dispensers were clean and full.
"Guests really want to get to their hotel room, including their bathroom, and not see any evidence of anybody else having been there," she said.
