The particular targets of the protest are two hotels being constructed on Tenerife.
On Sunday, organisers said the call had inspired people throughout Spain, with the message of overtourism striking a chord as far as Catalonia and the Balearic Islands.
“The support of the people has been wonderful,” they said, adding that some colleagues had already been on a four-day fast while they waited to hear from the hotels’ owners or local officials.
“The inaction of the government of the Canary Islands is shameful.”
In the past decade the number of international arrivals has jumped by a fifth to more than 14 million visitors a year.
The two new buildings, Puertito de Adeje-Hotel La Tejita and Hotel Cuna del Alma, have become totemic to the issue after residents resorted to sleeping in cars and even caves due to soaring house prices.
Speaking to Euronews, protesters for Canarias Se Agota said the islands were at their limit.
“We have nothing against individual tourists, but the industry is growing and growing and using up so many resources, and the island cannot cope,” said protest organiser Ivan Cerdena Molina.
Molina said he and his partner struggled to afford their apartment and spent most of their shared €900 ($1620) monthly income on €800 of rent, even in a cheaper part of Santa Cruz.
“Airbnb and Booking.com are like a cancer that is consuming the island bit by bit,” he said.
Ecologists in Action recently warned that almost 800,000 people — over a third of the islands — are at risk of poverty. Pressures and pricing from mass tourism were a factor in this.
Along with organised protests scheduled for this week, some residents have taken matters into their own hands with “guerilla” measures.
Recently, visitors to the islands reported fake signage appearing at beaches and popular areas reading “closed due to overtourism”.
Some graffiti is far more to the point: Last month city officials had to remove the slogan “Tourist go home” painted on the waterfront barriers.