The district has had one spike in facial eczema spores and continued hot still weather will bring another, Wanganui Veterinary Services general manager Tom Dinwiddie says.
Meatworks are already finding this season's lambs with clinical signs of the disease, including liver damage.
There was a sudden spike in facial eczema spores in mid-February, when the days and nights were hot, still and humid. The highest reading came from the Whangaehu Valley river flats - 140,000 spores per gram of pasture.
"That is very, very dangerous," Mr Dinwiddie said.
Average readings across the district are now at 60,000 to 70,000 spores, with the highest now at Maxwell, 90,000. Vets in Hunterville and Taihape have also reporting high readings.