DOC has not identified the two locations where the tampering happened in order to protect staff.
It has also told police of a case where 1080 baits were left in a DOC letterbox.
"People have a right to lawful protest, but I will not tolerate anyone putting my staff at risk as they go about their job of protecting our precious wildlife," Mr Sanson said.
State Services Commissioner Peter Hughes has backed DOC.
"This unacceptable behaviour is coming from a very small group of people and is rightly under police investigation," he said.
DOC's Battle for our Birds programme of aerial 1080 and ground-based predator control is being carried out over more than 750,000ha of reserve land.