The virus that plagued New York City in the original Prototype has returned. More importantly to new protagonist Heller, his wife and child were murdered, and he's out for revenge in a city that's in full lockdown. Shortly after entering, he's infected with the virus himself, gaining an impressive swath of superhuman abilities in the process.
What follows is a veritable slaughter: as Heller, your general approach to exposing cover-ups and crooked scientists is to hack apart and consume everyone in your path. There's no subtlety here: you can tell the main character is angry because he says as much.
Welcome to Prototype 2, the gaming equivalent of a late-80s Schwarzenegger flick.
The supporting cast of characters are even less interesting, whether it's a friendly priest who doesn't seem to mind you killing a ton of people, to a succession of soldiers and scientists whose memories are forced on you, inevitably posthumously. Regardless of who they are, you definitely won't be able to remember their names five seconds after they've shuffled off.
Of course, they play second fiddle to the main mystery, which involves Mercer - he of the original game - keeping an oddly close eye on your activities. Is he a friend? A lying foe? Will you still care by the time questions are answered? Probably not.