The 33-year-old poses a big step up in competition for Lookboonmee, who claimed a split decision win over Aleksandra Albu (3-2) in her UFC debut last October.
Lookboonmee addressed the change in opponent on social media, and said it didn't matter who she was fighting against.
"With only two weeks to go, I've got a new opponent– Angela Hill! I can't wait to face her in the octagon. My dreams are big, it doesn't (matter) who I face, I'll always be ready."
Hill isn't the only injury replacement to be fighting on the Auckland card, with five fighters who had booked bouts on the card now no longer taking part.
Australian light heavyweight Tyson Pedro was scheduled to make his long awaited return from injury on the card against Brazil's Vinicius Moreira, but was injured again in training camp and the fight was cancelled. Flyweight contender Rachael Ostovich withdrew from her scheduled bout against Shana Dobson due to undisclosed personal reasons, while Australian lightweight Jamie Mullarkey was also forced out of his fight against American Jalin Tuner due to injury.
Ostovich was replaced by Priscila Cachoeira of Brazil, while Mullarkey's replacement is expected to be confirmed by the UFC early next week, but it has been widely reported that Australian prospect Joshua Culibao is set to be named as the new fighter.
UFC Auckland card
Lightweight: Dan Hooker (NZ) v Paul Felder (five-round main event)
Strawweight: Karolina Kowalkiewicz v Yan Xiaonan
Flyweight: Kai Kara-France (NZ) v Tyson Nam
Welterweight: Jake Matthews (Aus) v Emil Meek
Light heavyweight: Jimmy Crute (Aus) v Michal Oleksiejczuk
Lightweight: Brad Riddell (NZ) v Magomed Mustafaev
Heavyweight: Ben Sosoli (NZ) v Marcos Rogério de Lima
Welterweight: Callan Potter (Aus) v Kenan Song
Lightweight: Jalin Turner v opponent yet to be confirmed
Featherweight: Kevin Aguilar v Zubaira Tukhugov
Strawweight: Loma Lookboonmee v Angela Hill
Welterweight: Maki Pitolo v Takashi Sato
Flyweight: Priscila Cachoeira v Shana Dobson