The co-main event will see bantamweight champion Henry Cejudo put his title on the line for the first time, taking on former champion Dominick Cruz, who makes his return to the octagon after injuries kept him sidelined for almost four years.
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Among the other fights on the card is the highly anticipated match up between heavyweight knockout artists Francis Ngannou and Jairzinho Rozenstruik, a welterweight bout between fan-favourites Donald Cerrone and Anthony Pettis, as well as a strawweight bout between Carla Esparza and Michelle Waterson which carries implications for the division's title picture.
Florida became an appealing option for the UFC following their most recent cancellation, with the WWE being allowed to film professional wrestling shows from its performance centre in Orlando. Earlier this month, the state's Governor Ron DeSantis issued an order regarding essential businesses, which included "employees at a professional sports and media production with a national audience – including any athletes, entertainers, production team, executive team, media team and any others necessary to facilitate including services supporting such production – only if the location is closed to the general public."
The UFC also confirmed two more events, on May 14 and 17 (NZ time). All three events will be held in Jacksonville.
UFC boss Dana White has remained determined to find a way to put on events during the coronavirus pandemic, going as far as securing an island to host fights that involve those on the roster outside of the United States.
After having to cancel the April 19 date, White told ESPN the island was expected to be ready around June, with the infrastructure being put in place.
"We will be the first sport back," White said earlier this month. "Fight island is real. It's a real thing. The infrastructure's being built right now, and that's really going to happen. And it will be on ESPN."
UFC 249 card
Main event: Tony Ferguson v Justin Gaethje for the interim lightweight title
Co-main: Henry Cejudo (c) v Dominick Cruz for the bantamweight championship
Heavyweight bout: Francis Ngannou v Jairzinho Rozenstruik
Featherweight bout: Jeremy Stephens v Calvin Kattar
Welterweight bout: Donald Cerrone v Anthony Pettis
Heavyweight bout: Greg Hardy v Yorgan de Castro
Heavyweight bout: Aleksei Oleinik v Fabricio Werdum
Light heavyweight bout: Ryan Spann v Sam Alvey
Strawweight bout: Carla Esparza v Michelle Waterson
Middleweight bout: Uriah Hall v Jacare Souza
Welterweight bout: Vicente Luque v Niko Price
Featherweight bout: Bryce Mitchell v Charles Rosa